Co Q10 Benefits and Side Effects
Physical health

Co Q10 Benefits and Side Effects: What You Need to Know

Introducing Coenzyme Q10, your body's natural antioxidant superhero! Also known as CoQ10, this powerful defender plays a vital role in energy production and keeps harmful free radicals at bay. By neutralizing them, CoQ10 helps safeguard your cells and tissues from oxidative damage. But that's not all - CoQ10 also offers health benefits like supporting a healthy heart, promoting graceful aging, and boosting your overall well-being. In this article, we will explore the benefits and side effects of CoQ10 and what you need to know before adding it to your wellness routine. 

What is Coenzyme Q10?

CoQ10 is a nutrient that plays a critical role in energy production and cellular health. 

Energy production

CoQ10 is found in every cell of your body, particularly in organs that require a lot of energy like the heart, liver, and kidneys. It works in conjunction with enzymes to generate adenosine triphosphate (ATP). This is the primary energy source for cellular processes. Without adequate levels of CoQ10, your cells may not be able to produce enough energy, leading to fatigue and other health issues. 

Antioxidant properties

Besides its role in energy production, CoQ10 has antioxidant properties that help protect your cells from oxidative damage. Oxidative damage is caused by free radicals. Free radicals are highly reactive molecules that can cause harm to your cells and tissues. If left unchecked, oxidative stress can contribute to chronic diseases like heart disease and cancer. CoQ10 helps neutralize these free radicals before they can cause harm, making it a powerful defender against oxidative damage.

Benefits of Coenzyme Q10

CoQ10 is linked to several health benefits that range from supporting heart health to promoting healthy aging. Here are some of the most notable ones:

Coenzyme Q10 and Congestive Heart Failure

Congestive heart failure (CHF) is a condition where the heart cannot pump enough blood to meet the body's needs. CHF can occur suddenly or over the long term (Chronic heart failure). CoQ10 supplements can improve symptoms and quality of life in people with CHF.  

Co Q10 and heart health

Coenzyme Q10 and Blood Pressure

High blood pressure is a common condition that can lead to heart disease and stroke. Some studies have shown that Co Q10 may help lower systolic blood pressure. 

Coenzyme Q10 and Cholesterol

Several studies have found that CoQ10 supplements can lower LDL (bad) cholesterol levels and increase HDL (good) cholesterol levels. Clinical Trials have shown that CoQ10 can reduce LDL cholesterol by up to 20%.

Coenzyme Q10 and Muscle Pain

Muscle pain is a common side effect of statins. Statins are a type of medication that is used to lower cholesterol levels. They work by blocking the production of cholesterol in the liver, but they can also reduce the amount of Co Q10 in the body. This can lead to muscle pain and weakness. Research has suggested that Co Q10 supplements may help alleviate muscle pain caused by statins. 

Coenzyme Q10 and Blood Clot Formation

CoQ10 has been found to have anticoagulant effects, which means it may help prevent blood clots from forming. This could be especially beneficial for people at risk of heart disease and stroke.

Coenzyme Q10 and Brain Health

Co Q10 may also have benefits for brain health. It may reduce harmful compounds that could increase your risk of diseases, such as Alzheimer's and Parkinson's disease.

Coenzyme Q10 and Blood Sugar

Some studies have suggested that CoQ10 may help reduce blood sugar levels and improve insulin sensitivity, which could benefit people with diabetes. 

Coenzyme Q10 and Migraines

Migraines are excruciating headaches that can last for hours or even days, causing significant disruption to daily life and productivity. Some studies have shown that Co Q10 may help reduce the frequency and severity of migraines. 

Coenzyme Q10 and Anti Aging

CoQ10 has powerful antioxidant properties that help protect your cells and tissues from oxidative damage. By neutralizing free radicals, CoQ10 helps keep your body's cells healthier for longer, promoting anti-aging effects.

CoenzymeQ10 and anti aging

Coenzyme Q10 and Physical Performance

CoQ10 also plays a role in physical performance, as it helps generate the energy needed for muscle contraction. Some studies have shown that CoQ10 may improve exercise tolerance and reduce fatigue.

In summary, Co Q10 benefits heart health, including benefits for people with cardiovascular disease, congestive heart failure, and high blood pressure. It also improves physical performance in athletes and reduces the frequency and severity of migraines. Furthermore, CoQ10 may play a role in healthy aging by protecting against age-related diseases. However, more research is needed to confirm these potential benefits.

Co Q10 in Dietary Supplements

While your body can produce CoQ10, factors like age and health status decrease the production of it. Dietary supplements ensure you are getting enough of this crucial nutrient. 

Before taking dietary supplements, it's important to note that Co Q10 supplements may cause side effects. 

Potential Side Effects

Co Q10 is generally considered safe for most people when taken in recommended doses. However, like any other supplement, it can cause side effects.

  • Co Q10 can cause an upset stomach, nausea, heartburn, vomiting, and loss of appetite.
  • Co Q10 may cause skin rash.
  • Co Q10 can lower blood pressure, which can cause dizziness, severe weakness, and feeling like you might pass out.

Co Q10 can also interact with certain medications:

Co Q10 and Blood Thinners: CoQ10 can interact with blood thinners like warfarin. Potentially increasing the risk of bleeding. 

Co Q10 and Chemotherapy Drugs: According to the National Cancer Institute, Co Q10 may interfere with the way some chemotherapy drugs work. The supplement could potentially reduce the effectiveness of these drugs in fighting cancer.

Co Q10 and blood pressure medications: CoQ10 may lower blood pressure, so it's crucial to monitor your blood pressure while taking Co Q10 alongside medications used to lower blood pressure.

Precautions to consider

  • If you have low blood pressure or are taking medication to lower your blood pressure, talk to your doctor before taking Co Q10 supplements.
  • If you are pregnant or breastfeeding, consult your healthcare provider before taking Co Q10 supplements.
  •  If you have a scheduled surgery, it is recommended to discontinue the intake of Co Q10 at least two weeks before the surgery. This precautionary measure is crucial as Co Q10 interferes with blood clotting processes.
  • Always consult your doctor before adding new supplements to your regimen, especially if you have a pre-existing medical condition or are taking medication.

In conclusion, evidence suggests that Co Q10 has numerous health benefits, but more research is needed to understand its effects. It's important to consult with your doctor before starting any new supplement and to monitor for potential side effects. 

CoQ10 precautions to consider

Clinical Trials on Coenzyme Q10

Clinical trials are research studies that involve human volunteers and test the safety and effectiveness of new treatments, therapies, or interventions.

There have been many clinical trials investigating the potential benefits of CoQ10. Here are a few examples:

  • In a study published in the Journal of the American College of Cardiology, researchers found that CoQ10 supplementation improved heart function in patients with heart failure. The study involved 420 patients randomly assigned to receive either CoQ10 or a placebo for two years. The CoQ10 group had a lower risk of major adverse cardiovascular events, such as heart attack or stroke, than the placebo group.
  • Another study, published in the Journal of Neurology, found that CoQ10 supplementation may slow the progression of Parkinson's disease. The study involved 80 patients with early Parkinson's disease who were randomly assigned to receive either CoQ10 or a placebo for 16 months. The CoQ10 group had significantly less decline in motor function compared to the placebo group.
  • In a randomized controlled trial published in the Journal of Clinical Endocrinology & Metabolism, researchers found that CoQ10 supplementation improved glucose metabolism and lipid profiles in women with polycystic ovary syndrome (PCOS). The study involved 86 women with PCOS who were randomly assigned to receive either CoQ10 or vitamin E for 8 weeks. The CoQ10 group had significant reductions in fasting blood glucose and insulin levels. Additionally, there were improvements observed in the cholesterol levels of the participants in comparison to those in the placebo group.

Overall, these clinical trials suggest that CoQ10 benefits heart health, Parkinson's disease, and glucose metabolism in women with PCOS. 


What is Mitochondrial Dysfunction?

Mitochondrial dysfunction is a term used to describe a decline in the function of mitochondria, which are organelles responsible for producing energy in cells. This can lead to various health issues, including heart disease, neurological disorders, and chronic fatigue syndrome. CoQ10 plays a crucial role in supporting mitochondrial function and may be beneficial in preventing or treating conditions related to mitochondrial dysfunction. 

Why is Co Q 10 important for blood and muscle tissue?

CoQ10 is important for blood and muscle tissue because these organs require a significant amount of energy. The heart, in particular, demands high energy as it constantly pumps oxygenated blood throughout the body. CoQ10 plays a vital role in supporting the production of ATP (adenosine triphosphate). ATP is the main source of energy for cells, including those found in blood and muscle tissues. 

Who should avoid taking Coenzyme Q10?

If you are pregnant, breastfeeding, have low blood pressure or have a pre-existing medical condition, it is crucial to consult with your doctor before taking CoQ10 supplements. Additionally, if you are scheduled for surgery, it's best to stop taking CoQ10 at least two weeks before the surgery. 


Coenzyme Q10 is a natural nutrient that can be found in every cell of your body and plays an important role in maintaining your overall health. Not only does it provide energy to our cells, but it also helps protect cells from harmful free radicals. Supplementing with CoQ10 can offer numerous benefits for your overall well-being. From supporting heart health and enhancing brain function to controlling cholesterol levels, fighting migraines, and promoting anti-aging effects, CoQ10 is a valuable addition to your daily routine. As always, it's best to consult your doctor before taking any new supplement and carefully monitor for any side effects. 


Mayo Clinic. Coenzyme Q10

Cleveland HeartLab, Inc. CoQ10: What are the Heart Health Benefits?